Summary: Histone lysine demethylases (KDMs) play critical roles in oncogenesis and therefore may be effective targets for anticancer therapy.Using a time-resolved fluorescence resonance energy transfer demethylation screen assay, in combination with multiple orthogonal validation approaches, we identified geldanamycin and its analog 17-DMAG as KDM
Abstract Single particle resolution is Ingredient Bins a requirement for numerous experimental protocols that emulate the dynamics of small systems in a bath.Here, we accurately resolve through atom counting the stochastic dynamics of a few sodium atoms in presence of a cold potassium cloud.This capability enables us to rule out the effect of inter
The insufficient supply of serviced land at affordable prices for the urban poor and the need for regularization of the consequent illegal occupations in urban areas are two of the most important issues on the Latin American land policy agenda.Taking a structural/integrated view on the functioning of the Hard Top Headliners / Deadeners urban land m
Point absorbers are extensively employed in wave energy conversion.In this work, we studied the point absorber with the buoy of a vertical cylindrical shape.Wave power absorption is obtained through the relative motion between the buoy and an internal mass.Three power-absorption degrees of freedom are investigated, i.e., surge, heave, and pitch, to
Brain cancers, a global menace with high mortality rates, remain a profound challenge, particularly in treating the most lethal type of malignant tumors like glioblastoma multiforme (GBM).The crucial need for prompt identification and precise prognosis drives the exploration of exosomes as non-invasive tools.Exosomes are generated by various cells,